U.S. Route 250 is a part of the U.S. Highway System that runs from Sandusky, Ohio to Richmond, Virginia. In Virginia, the highway runs 166.74 miles (268.34 km) from the West Virginia state line near Hightown east to its eastern terminus at US 360 in Richmond. US 250 is the main east–west highway of Highland County, which is known as Virginia's Little Switzerland; the highway follows the path of the 19th century Staunton and Parkersburg Turnpike. From Staunton east to Richmond, the highway serves as the local complement to Interstate 64 (I-64), roughly following the 18th century Three Notch'd Road through Waynesboro and Charlottesville on its way through the Shenandoah Valley, its crossing of the Blue Ridge Mountains at Rockfish Gap, and the Piedmont. In the Richmond metropolitan area, US 250 is known as Broad Street, a major thoroughfare through the city's West End and downtown areas.

U.S. Route 360 is a spur route of US 60. The U.S. Highway runs 225.3 miles (362.6 km), entirely within the state of Virginia, from US 58 Business, Virginia State Route 293, and SR 360 in Danville east to SR 644 in Reedville. US 360 connects Danville, South Boston, Keysville and Burkeville in Southside Virginia with the state capital of Richmond. The highway connects Richmond with Tappahannock on the Middle Peninsula and the eastern Northern Neck, where it serves as the primary route through Northumberland County. US 360 is a four-lane divided highway for almost all of its length.