U.S. Route 250 (US 250) is a United States Numbered Highway that runs from Sandusky, Ohio, to Richmond, Virginia. Within the state of West Virginia, the route runs from the Ohio border in Wheeling to the Virginia border near Thornwood.

Wheeling is a city in the U.S. state of West Virginia. Located almost entirely in Ohio County, of which it is the county seat, it lies along the Ohio River in the foothills of the Appalachian Mountains and also contains a tiny portion extending into Marshall County. Wheeling is located about 60 miles (96 km) west of Pittsburgh and is the principal city of the Wheeling metropolitan area. As of the 2020 census, the city had a population of 27,062, and the metro area had a population of 139,513. It is the fifth most populous city in West Virginia, and the most populous in the state’s Northern Panhandle.