U.S. Route 26 (US 26) is a major cross-state United States Numbered Highway with its western terminus in the U.S. state of Oregon, connecting US 101 on the Oregon Coast near Seaside with the Idaho state line east of Nyssa. Local highway names include the Sunset Highway No. 47, Mount Hood Highway No. 26, and John Day Highway No. 5 before continuing into Idaho and beyond.

Interstate 5 (I-5) in the U.S. state of Oregon is a major Interstate Highway that traverses the state from north to south. It travels to the west of the Cascade Mountains, connecting Portland to Salem, Eugene, Medford, and other major cities in the Willamette Valley and across the northern Siskiyou Mountains. The highway runs 308 miles (496 km) from the California state line near Ashland to the Washington state line in northern Portland, forming the central part of Interstate 5's route between Mexico and Canada.