U.S. Route 280 is a spur of U.S. Highway 80. It currently runs for 392 miles (631 km) from Blitchton, Georgia, at US 80 to Birmingham, Alabama at I-20/I-59. For much of its route, US 280 travels through rural areas and smaller cities in southern Georgia and east central Alabama. Once the highway approaches Birmingham, it is a major suburban route. Numerous shopping centers are located on US 280 throughout northern Shelby County and southern Jefferson County.

Sylacauga is a city in Talladega County, Alabama, United States. At the 2020 census, the population was 12,578.