U.S. Route 29 (US 29), internally designated by the Alabama Department of Transportation (ALDOT) as State Route 15 (SR 15), is a southwest–northeast state highway across the southeastern part of the U.S. state of Alabama. US 29 and SR 15 traverse Alabama in a general northeast–southwest slope. It has never been a major route in the state; its significance was completely overshadowed with the completion of Interstate 65 (I-65) and I-85 during the 1970s. Today, US 29 and SR 15 serve primarily to connect numerous smaller towns and cities in the southwest, south-central, and eastern parts of Alabama.

Interstate 85 (I-85) is a part of the Interstate Highway System that runs from Montgomery, Alabama, to Petersburg, Virginia. In Alabama, the Interstate Highway runs 80 miles (130 km) from I-65 in Montgomery northeast to the Georgia state line near Valley. Although it is nominally north–south as it carries an odd number, I-85 travels east–west through the state. It is the primary highway between Montgomery and Atlanta. The Interstate also connects Montgomery with Tuskegee, Auburn, Opelika, and, indirectly, Phenix City and Columbus, Georgia.