U.S. Route 2 (US 2) is a part of the United States Numbered Highway System that is split into two segments. Its eastern segment runs from Rouses Point, New York, to Houlton, Maine. In Vermont, US 2 extends 150.518 miles (242.235 km) from the New York state line in Alburgh to the New Hampshire state line in Guildhall. West of Vermont, US 2 continues into New York for another 0.87 miles (1.40 km) to an intersection with US 11 in Rouses Point. US 2 passes through the cities of Burlington and Montpelier as it traverses the state. The highway parallels Interstate 89 (I-89) between these two cities. The Burlington to Montpelier route was first laid out as a toll road in the early 19th century. It was later incorporated into the transcontinental auto trail known as the Theodore Roosevelt International Highway in 1919 before being designated as part of US 2 in 1926.

Milton is a town in Chittenden County, Vermont, United States. As of the 2020 census, the population was 10,723. According to local legend, the town was named for the English poet John Milton, but the name most likely originated from William FitzWilliam, 4th Earl FitzWilliam, who held the title Viscount Milton and was a supporter of independence for the colonies during the American Revolution.