U.S. Route 2 (US 2) is a part of the United States Numbered Highway System that is split into two segments. Its eastern segment runs from Rouses Point, New York, to Houlton, Maine. In Vermont, US 2 extends 150.518 miles (242.235 km) from the New York state line in Alburgh to the New Hampshire state line in Guildhall. West of Vermont, US 2 continues into New York for another 0.87 miles (1.40 km) to an intersection with US 11 in Rouses Point. US 2 passes through the cities of Burlington and Montpelier as it traverses the state. The highway parallels Interstate 89 (I-89) between these two cities. The Burlington to Montpelier route was first laid out as a toll road in the early 19th century. It was later incorporated into the transcontinental auto trail known as the Theodore Roosevelt International Highway in 1919 before being designated as part of US 2 in 1926.

Rouses Point is a village in Clinton County, New York, United States, along the 45th parallel. The population was 2,209 at the 2010 census. The village is named after Jacques Rouse, a French Canadian soldier who fought alongside the Americans during their war for independence. The village is on the western shore of Lake Champlain at the source of the Richelieu River. Also located in the northeastern corner of the town of Champlain, it is north of the city of Plattsburgh and is on the Canada–United States border.