U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey, meeting the New Jersey Turnpike at exit 2. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.

Pennsylvania Route 285 is an 27.1-mile-long (43.6 km), east–west state highway located in Crawford County in Pennsylvania, United States. The western terminus is the Ohio state line on Lake Pymatuning, where the road becomes Ohio State Route 85. The eastern terminus is at PA 173 in Cochranton.