U.S. Route 33 (US 33) is part of the United States Numbered Highway System that runs from Richmond, Virginia, to Elkhart of the US state of Indiana. In Indiana, it is a state road that enters the state at the Ohio state line between Willshire, Ohio, and Pleasant Mills, Indiana. The 106.217 miles (170.940 km) of US 33 that lie within Indiana serve as a major conduit. All of the highway is listed on the National Highway System. Various sections are rural two-lane highway, urbanized four-lane divided expressway and the Lincoln Highway. The northernmost community along the highway is Elkhart. The highway ends at an interchange in southern Elkhart after serving the northeastern region of Indiana. US 33 passes through farm fields and urban areas.

State Road 101 in the U.S. state of Indiana is a north–south state highway in the eastern portion of Indiana that exists in four sections with a combined length of 79.42 miles (127.81 km).