U.S. Route 33 (US 33) is a United States Numbered Highway running from near Elkhart, Indiana, to Richmond, Virginia. Within the state of Ohio, it is a predominantly southeast–northwest highway running from west of Willshire before crossing over into West Virginia via the Ravenswood Bridge over the Ohio River. The route runs through largely rural territory throughout most of the state's west-central, central, and southeastern regions, although it also passes through large portions of downtown Columbus.

US Highway 127 (US 127) is a part of the United States Numbered Highway System that runs from Chattanooga, Tennessee, to the Lower Peninsula of Michigan. In Ohio, the highway runs 194.27 miles (312.65 km) from the Ohio River in Cincinnati to the Michigan state line north of West Unity. US 127 runs south to north in Ohio's westernmost counties along the border of Indiana. The highway is a main route connecting many small towns, including eight county seats. The highway was first designated in 1926. Its route ended in downtown Toledo before being realigned to its current route in 1930.