U.S. Route 34 (US 34) is an east–west highway In the state of Illinois that runs from the Iowa state line at Gulfport, west of Galesburg, to Illinois Route 43 (IL 43) and Historic U.S. Route 66 at Harlem Avenue in Berwyn. The entire highway in Illinois is named the Walter Payton Memorial Highway after Pro Football Hall of Famer Walter Payton, who wore #34 for the Chicago Bears. The highway is 211.37 miles (340.17 km) long within the state.

Illinois Route 43 is a 60.30-mile-long (97.04 km) major north–south state highway in the U.S. state of Illinois. It runs from U.S. Route 30 (US 30) in Frankfort north to the large intersection of IL 120 and US 41 in Waukegan.