U.S. Route 395, also known as U.S. Highway 395, is a north–south United States Numbered Highway that traverses the inland areas of the western states of California, Nevada, Oregon, and Washington. It travels for over 1,300 miles (2,100 km) from a junction in the Mojave Desert at Interstate 15 (I-15) in Hesperia to the Canada–U.S. border near Laurier, Washington. Major cities along its route include Carson City and Reno in Nevada; Kennewick and Pasco in Washington's Tri-Cities region; and Spokane, Washington. US 395 is an auxiliary route of US 95 but never intersects its parent route, which runs further east.

The Mojave Desert is a desert in the rain shadow of the southern Sierra Nevada mountains and Transverse Ranges in the Southwestern United States. Named for the indigenous Mohave people, it is located primarily in southeastern California and southwestern Nevada, with small portions extending into Arizona and Utah.