U.S. Route 395 (US 395) is an 85-mile-long (137 km) United States Numbered Highway near Lake Tahoe in the state of Nevada. It traverses the state after entering from California in Topaz Lake and crosses back into California near Hallelujah Junction. US 395 serves the cities of Gardnerville, Minden, Carson City and Reno. All of US 395 north of Carson City is a freeway and is built up to Interstate Highway standards. Part of the freeway section is also designated as Interstate 580 (I-580). US 395 is an important regional highway, serving the communities of Western Nevada, connecting them to other major communities via California, and it is the only major north–south arterial for the geographically isolated region.

Gardnerville is an unincorporated town in Douglas County, Nevada, adjacent to the county seat of Minden. The population was 6,211 at the 2020 census.