U.S. Route 421 is a part of the U.S. Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In Virginia, the U.S. Highway runs 69.23 miles from the Tennessee state line b

State Route 65, formerly State Route 66, is a primary state highway in the U.S. state of Virginia. The state highway runs 34.06 miles from U.S. Route 23, US 58, and US 421 in Clinchport north to US 58