U.S. Route 422 (US 422) is a 271-mile-long (436 km) spur route of US 22 split into two segments in the U.S. states of Ohio and Pennsylvania. The western segment of US 422 runs from downtown Cleveland, Ohio, east to Ebensburg, Pennsylvania. The eastern segment, located entirely within Pennsylvania, runs from Hershey east to King of Prussia, near Philadelphia. US 422 Business serves as a business route into each of four towns along the way.
US 422 eastbound past US 422 Bus. east of New Castle, PA
US 422 westbound on Chocolate Avenue in Hershey
US 422 eastbound east of Lebanon
US 422 westbound approaching US 222 in Wyomissing
U.S. Route 22 (US 22) is a major west–east route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange.
Old US 22 marker located near the intersection of US 22 and SR 207 in Pickaway County, Ohio
View east along US 22 east of County Route 13 (CR 13) in Weirton, West Virginia
US 22 eastbound in Colonial Park, Pennsylvania, east of Harrisburg
View east along US 22 at Cramer Avenue in Green Brook, New Jersey
