U.S. Route 425 is a north–south United States highway that travels in the U.S. states of Mississippi, Louisiana, and Arkansas. It was first commissioned in 1989.

Arkansas Highway 35 is a designation for three state highways in southeast Arkansas. One segment of 36.4 miles runs from Macon Lake Road at Dewey north to U.S. Route 278 in Monticello. A second segmen