U.S. Route 425 (US 425) is a north–south United States highway that travels in the U.S. states of Mississippi, Louisiana, and Arkansas. It was first commissioned in 1989.

Pine Bluff is the 10th most populous city in the US state of Arkansas and the county seat of Jefferson County. It is the principal city of the Pine Bluff Metropolitan Statistical Area and part of the Little Rock-North Little Rock-Pine Bluff Combined Statistical Area. The population of the city was 41,253 in the 2020 census.