U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as
Failure of the Mississippi Highway 25 N/U.S. Route 45 S bridge over the Tombigbee River relief (Big Nichols Creek)/Tennessee–Tombigbee Waterway in Aberdeen, Mississippi, during the March 1955 floods.
US 45 Bypass signage in Jackson, Tennessee
U.S. Route 45 crosses the Ohio River between Kentucky and Illinois on the Brookport Bridge.
The highway near Oshkosh, Wisconsin
Columbus is a city in and the county seat of Lowndes County, on the eastern border of Mississippi, United States, located primarily east, but also north and northeast of the Tombigbee River, which is
Postcard of steamer American on Tombigbee River at Columbus, c. 1890-1920