U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route U.S. Route 60 at Ocean View to Frankfort, Kentucky, intersecting its parent route once again. It passes through the states of Virginia, West Virginia, and Kentucky. It goes through the cities and towns of Norfolk, Portsmouth, Suffolk, Petersburg, Farmville, Lynchburg, Roanoke, Christiansburg, Blacksburg, Tazewell, and Grundy, in Virginia; Princeton and Bluefield in West Virginia; and Pikeville, Georgetown, and Frankfort in Kentucky.

U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as General Booth Boulevard, just south of the city's Oceanfront resort district at the intersection of Rudee Point Road and Harbor Point. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.