U.S. Route 50 (US-50) is a major east–west route of the U.S. Highway system, stretching just over 3,000 miles (4,800 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 in Ocean City, Maryland, on the Atlantic Ocean. In the U.S. state of Kansas, US-50 is a main east–west highway serving the southwestern, central and northeastern parts of the state. Kansas City is the only metropolitan area US-50 serves in the state, but the highway does serve several other larger towns in Kansas such as Garden City, Dodge City, Hutchinson, Newton and Emporia.

Garden City is a city in and the county seat of Finney County, Kansas, United States. As of the 2020 census, the population of the city was 28,151. The city is home to Garden City Community College and the Lee Richardson Zoo, the largest zoological park in western Kansas.