U.S. Route 51 (US 51) in the U.S. state of Illinois, is a main north–south artery that runs from the Ohio River north to the Wisconsin border, a distance of 415.95 miles (669.41 km).

Interstate 64 (I-64) in the US state of Illinois is a major east–west Interstate Highway that runs through southern Illinois from the St. Louis metropolitan area east to the Indiana state line near Grayville, Illinois. It travels a distance of 130.4 miles (209.9 km).