U.S. Highway 52 (US 52) enters the state of Minnesota at the unincorporated community of Prosper, north of the town of Burr Oak, Iowa. The route is marked north–south in Minnesota along its independent segment from the Iowa state line to downtown St. Paul. US 52 is not signed along the length of its concurrency with Interstate 94 (I-94) from downtown St. Paul to the North Dakota state line at Moorhead and Fargo.

Interstate 94 (I-94) in the US state of Minnesota runs 259 miles (417 km) east–west through the central portion of the state. The highway connects the cities of Moorhead, Fergus Falls, Alexandria, St. Cloud, Minneapolis, and Saint Paul. Authorized in 1956, it was mostly constructed in the 1960s. For its whole length, it runs concurrently with either US Highway 52 (US 52) or US 12.