U.S. Route 52 in Virginia runs north–south through the southwestern part of the state along the Interstate 77 (I-77) corridor. Though an even-numbered U.S. route, it is signed north–south in Virginia. In some other states along its route, it is signed east–west. The Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa.

Interstate 77 (I-77) in the US state of Virginia is a 67-mile (108 km) north–south Interstate Highway serving Hillsville, Wytheville, and Bland. Running parallel to US Route 52 (US 52), I-77 passes through the Big Walker Mountain Tunnel and East River Mountain Tunnel, the latter on the West Virginia state line and one of only two land vehicular tunnels to cross a state line.