U.S. Route 59 (US-59) is a part of the U.S. Highway System that runs from the Mexico–US border in Laredo, Texas, as a continuation of Mexican Federal Highway 85D north to the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. In the U.S. state of Kansas, US-59 is a main north–south highway that travels from Chetopa to Atchison.

K-16 is a 114.460-mile-long (184.206 km) state highway in the U.S. State of Kansas. K-16's western terminus is at a junction with U.S. Route 77 (US-77) just north of Randolph and the eastern terminus is at US-24 and US-40 in Tonganoxie. Along the way K-4 intersects many major thoroughfares including US-75 in Holton, K-4 near Valley Falls and US-59 from west of Winchester to south of Oskaloosa.