U.S. Route 59 (US-59) is a part of the U.S. Highway System that runs from the Mexico–US border in Laredo, Texas, as a continuation of Mexican Federal Highway 85D north to the Lancaster–Tolstoi Border Crossing on the Canada–US border, where it continues as Manitoba Highway 59. In the U.S. state of Kansas, US-59 is a main north–south highway that travels from Chetopa to Atchison.

U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.