U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina, to U.S. Route 52, in Mount Airy, North Carolina. In North Carolina, it is one of the main north-south corridors connecting the cities of Salisbury, Mocksville, and Mount Airy.

Hampton is a town in Hampton County, South Carolina, United States. The population was 2,808 at the 2010 census. It is the county seat of Hampton County. The town and the county are named after Wade Hampton III, a Confederate general in the Civil War.