U.S. Route 60 (US 60) is an east–west United States Highway within Arizona. The highway runs for 369 miles (594 km) from a junction with Interstate 10 near Quartzsite to the New Mexico state line near Springerville. As it crosses the state, US 60 overlaps at various points: I-17, I-10, SR 77, SR 260, US 191, and US 180. Between Wickenburg and Phoenix, the route is known as Grand Avenue. From Tempe to Apache Junction, it is known as the Superstition Freeway.

In the U.S. state of Arizona, Interstate 10 (I‑10), the major east–west Interstate Highway in the United States Sun Belt, runs east from California, enters Arizona near the town of Ehrenberg and continues through Phoenix and Tucson and exits at the border with New Mexico near San Simon. The highway also runs through the cities of Casa Grande, Eloy, and Marana. Segments of the highway are referred to as either the Papago Freeway, Inner Loop, or Maricopa Freeway within the Phoenix area and the Pearl Harbor Memorial Highway outside metro Phoenix.