U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. In Oklahoma, US-60 has three business routes, serving Tonkawa, Ponca City, and Seneca. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51).

Enid is the ninth-largest city in the U.S. state of Oklahoma. It is the county seat of Garfield County. As of the 2020 census, the population was 51,308. Enid was founded during the opening of the Cherokee Outlet in the Land Run of 1893, and is named after Enid, a character in Alfred, Lord Tennyson's Idylls of the King. In 1991, the Oklahoma state legislature designated Enid the "purple martin capital of Oklahoma." Enid holds the nickname of "Queen Wheat City" and "Wheat Capital" of Oklahoma and the United States for its immense grain storage capacity, and has the third-largest grain storage capacity in the world.