U.S. Route 60 (US 60) runs northwest to southeast across the central and southern portions of West Virginia. It runs from the Kentucky state line at Catlettsburg, Kentucky, and Kenova. The road passes through Huntington, Charleston, and White Sulphur Springs. The route exits the state into Virginia, running concurrently with Interstate 64 (I-64) east of White Sulphur Springs. Most of US 60's route through West Virginia is part of and even signed in several areas as the Midland Trail, a National Scenic Byway.

Kenova is a city in Wayne County, West Virginia, United States, situated at the confluence of the Ohio and Big Sandy rivers. The city's name is a portmanteau of Kentucky, Ohio, and Virginia (Va), owing to its location where the three states met before the creation of West Virginia. The population was 3,030 at the 2020 census. It is part of the Huntington–Ashland metropolitan area.