U.S. Highway 61 (US 61) is a U.S. Highway in southeastern and east-central Minnesota, which runs from the Mississippi River Bridge at La Crescent and continues north to its northern terminus at its junction with Interstate 35 (I-35) at the city of Wyoming.

Lake City is a city in Goodhue and Wabasha counties in the U.S. state of Minnesota. It lies along Lake Pepin, a wide portion of the Mississippi River. The population was 5,252 at the 2020 census. Most of Lake City is located within Wabasha County with only a small portion in Goodhue County. Lake City is part of the Rochester, Minnesota Metropolitan Statistical Area.