U.S. Route 62 is a part of the U.S. Highway System that travels from the United States–Mexico border at El Paso, Texas, to Niagara Falls, New York. In the U.S. state of New York, US 62 extends 102.77 miles (165.39 km) from the New York–Pennsylvania border south of Jamestown to an intersection with New York State Route 104 in downtown Niagara Falls, bypassing the city of Jamestown and serves the cities of Buffalo and Niagara Falls, along with several villages. It is the only north–south mainline U.S. highway in Western New York. US 62 was extended into New York c. 1932 and originally was concurrent with the state highways that had previously been designated along its routing—namely NY 18, NY 60, NY 83 and NY 241. These concurrencies were eliminated individually during the 1940s and 1960s. The last of the four concurrencies, with NY 18 from Dayton to Niagara Falls, was removed c. 1962. US 62 has one special route, US 62 Business, located in Niagara Falls. US 62 Business is a former routing of US 62 within the city and was once NY 62A.

Niagara Falls is a city in Niagara County, New York, United States. As of the 2020 census, the city had a total population of 48,671. It is adjacent to the Niagara River, across from the city of Niagara Falls, Ontario, and named after the famed Niagara Falls which they share. The city is within the Buffalo–Niagara Falls metropolitan area and the Western New York region.