U.S. Route 62 (US 62) is a United States Numbered Highway spanning through Ohio from Aberdeen to Hubbard. Near Killbuck, in Amish Country, it is also marked as an Ohio Byway.

U.S. Route 52 runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, Portsmouth, and Ironton. For its first 19 miles (31 km) or so, the highway runs concurrently with Interstate 74 (I-74) and I-75 before it winds through downtown Cincinnati for several miles. The route is primarily two lanes between New Richmond and West Portsmouth, Ohio, where it becomes a four-lane partial access highway until it exits the state near Chesapeake.