U.S. Route 65 is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway.

Newellton is a town in northern Tensas Parish in the northeastern part of the U.S. state of Louisiana. The population is 1,187 in the 2010 census, a decline of 255 persons, or 17 percent, from the 2000 tabulation of 1,482. The average age of the population there is 41 years.