U.S. Route 66 or U.S. Highway 66 was one of the original highways in the United States Numbered Highway System. It was established on November 11, 1926, with road signs erected the following year. The highway, which became one of the most famous roads in the United States, ran from Chicago, Illinois, through Missouri, Kansas, Oklahoma, Texas, New Mexico, and Arizona before terminating in Santa Monica in Los Angeles County, California, covering a total of 2,448 miles (3,940 km).

Oklahoma is a landlocked state in the South Central region of the United States. It borders Texas to the south and west, Kansas to the north, Missouri to the northeast, Arkansas to the east, New Mexico to the west, and Colorado to the northwest. Partially in the western extreme of the Upland South, it is the 20th-most extensive and the 28th-most populous of the 50 United States. Its residents are known as Oklahomans and its capital and largest city is Oklahoma City. The state's name is derived from the Choctaw words okla, 'people' and humma, which translates as 'red'. Oklahoma is also known informally by its nickname, "The Sooner State", in reference to the Sooners, settlers who staked their claims in formerly American Indian-owned lands until the Indian Appropriations Act of 1889 authorized the Land Rush of 1889 opening the land to white settlement.