U.S. Route 67 is a major U.S. highway in the state of Texas. It runs from the U.S.–Mexico border west of Presidio to Texarkana at the Arkansas state line. US 67 is part of the La Entrada al Pacifico international trade corridor from its southern terminus to US 385 in McCamey.

Presidio is a city in Presidio County, Texas, United States. It is situated on the Rio Grande River, on the opposite side of the U.S.–Mexico border from Ojinaga, Chihuahua. The name originates from Spanish and means "fortress". The population was 4,169 at the 2000 census, and had increased to 4,426 as of the 2010 US census.