U.S. Route 69 is a north–south United States highway that runs from Port Arthur, Texas to Albert Lea, Minnesota. In Texas, US 69 runs from Port Arthur near the Gulf of Mexico to the Texas–Oklahoma state line just north of Denison.

Denison is a city in Grayson County, Texas, United States, 1 mile (1.6 km) south of the Texas–Oklahoma border. Its population was 24,479 at the 2020 and 22,682 at the 2010 censuses. Denison is part of the Texoma region and is one of two principal cities in the Sherman–Denison metropolitan statistical area. Denison is the birthplace of U.S. President Dwight D. Eisenhower.