U.S. Route 6 (US 6) in the state of Illinois is an east–west arterial surface road that runs 179.88 miles (289.49 km) from the city of Moline in the Quad Cities area to Lansing at the Indiana state line.

Interstate 74 (I-74) in the US state of Illinois is a major northwest–southeast Interstate Highway that runs across the central portion of the state. It runs from the Iowa state line at the Mississippi River near the city of Rock Island and runs southeast to the Indiana state line east of Danville, a distance of 220.34 miles (354.60 km). The highway runs through the major cities of Champaign, Bloomington, Peoria, and Moline.