U.S. Highway 6 (US-6) in the U.S. state of Nebraska is a United States Numbered Highway which goes from the Colorado border west of Imperial in the west to the Iowa border in the east at Omaha. Significant portions of the highway are concurrent with other highways, most significantly, US-34 between Culbertson and Hastings. Also, from Milford east to the Iowa border, the highway is closely paralleled by Interstate 80 (I-80). Large portions of the route parallel the Chicago, Burlington and Quincy Railroad.

Hastings is a city and the county seat of Adams County, Nebraska, United States. The population was 25,152 at the 2020 census, making it the 8th most populous city in Nebraska.