U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.

U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as General Booth Boulevard, just south of the city's Oceanfront resort district at the intersection of Rudee Point Road and Harbor Point. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.