U.S. Route 75 is a part of the United States Numbered Highway System that runs for 1,239 miles (1,994 km) from Dallas, Texas to Kittson County, Minnesota where it ends just short of the Canada–United States border. Within the State of Nebraska it is a state highway that enters Nebraska on the Kansas state line about 9 miles (14 km) south of Dawson and travels north across the extreme eastern portion of the state, to the Nebraska–Iowa border in South Sioux City where it crosses the Missouri River along a concurrency with Interstate 129. The northern 210 miles (340 km) of the route generally travels parallel to the Missouri River. The 87.32-mile (140.53 km) section between the I-680 interchange in Omaha and the Interstate 129 interchange is designated the Lewis & Clark Scenic Byway, one of nine scenic byways in the state.

South Sioux City is a city in Dakota County, Nebraska, United States. It is located immediately across the Missouri River from Sioux City, Iowa, and is part of the Sioux City, IA-NE-SD Metropolitan Statistical Area. As of the 2010 census, the city population was 13,353, making it the 14th most populous city in Nebraska.