U.S. Route 80 or U.S. Highway 80 (US 80) is a major east–west United States Numbered Highway in the Southern United States, much of which was once part of the early auto trail known as the Dixie Overland Highway. As the "0" in the route number indicates, it was originally a cross-country route, from the Pacific Ocean to the Atlantic Ocean. Its original western terminus was at Historic US 101 in San Diego, California. However, the entire segment west of Dallas, Texas, has been decommissioned in favor of various Interstate Highways and state highways. Currently, the highway's western terminus is at an interchange with Interstate 30 (I-30) on the Dallas–Mesquite city line. Its eastern terminus is in Tybee Island, Georgia near the Atlantic Ocean. Between Jonesville, Texas and Kewanee, Mississippi, US 80 runs parallel to or concurrently with Interstate 20. It also currently runs through Dallas, Texas; Shreveport, Louisiana; Jackson, Mississippi; Montgomery, Alabama; Columbus, Georgia; Macon, Georgia; and Savannah, Georgia.

Jackson is the capital of and the most populous city in the U.S. state of Mississippi. Along with Raymond, Jackson is one of two county seats for Hinds County. The city had a population of 153,701 at the 2020 census, a significant decline from 173,514, or 11.42%, since the 2010 census, representing the largest decline in population during the decade of any major U.S. city. Jackson is the anchor for the Jackson metropolitan statistical area, the largest metropolitan area located entirely in the state and the tenth-largest urban area in the Deep South. With a 2020 population of nearly 600,000, metropolitan Jackson is home to over one-fifth of Mississippi's population. The city sits on the Pearl River and is located in the greater Jackson Prairie region of Mississippi. Jackson is the only city in Mississippi with a population exceeding 100,000 people.