U.S. Route 80 was a major transcontinental highway in the U.S. state of New Mexico from November 11, 1926, to October 12, 1991. Nationally, US 80 stretched from San Diego, California to Tybee Island, Georgia, going through southern New Mexico from El Paso, Texas, through the towns of Las Cruces, Deming and Lordsburg before entering Arizona. US 80 was a modest 191 miles (307 km) long and was eventually replaced by Interstate 10 leading to the complete removal of US 80 in New Mexico. State Road 80 is a remnant of this route.

Lordsburg is a city in and the county seat of Hidalgo County, New Mexico, United States. Hidalgo County includes the southern "bootheel" of New Mexico, along the Arizona border. The population was 2,797 at the 2010 census, down from 3,379 in 2000.