U.S. Route 81 or U.S. Highway 81 is a major north–south U.S. highway that extends for 1,220 miles in the central United States and is one of the original United States Numbered Highways established in

Meridian Highway was a United States auto trail in the early twentieth century. It roughly followed the path of present-day U.S. Route 81 from Pembina, North Dakota to Fort Worth, Texas, and Interstat