U.S. Route 82 is a section of a west-east highway that travels through Mississippi. It starts at the Arkansas state line at Refuge and ends at the Alabama state line east of Columbus.

Columbus is a city in and the county seat of Lowndes County, on the eastern border of Mississippi, United States, located primarily east, but also north and northeast of the Tombigbee River, which is also part of the Tennessee-Tombigbee Waterway. It is approximately 146 miles (235 km) northeast of Jackson, 92 miles (148 km) north of Meridian, 63 miles (101 km) south of Tupelo, 60 miles (97 km) northwest of Tuscaloosa, Alabama, and 120 miles (193 km) west of Birmingham, Alabama.