U.S. Highway 83, part of the United States Numbered Highway System, runs from the Mexican border in Brownsville, Texas, to the Canadian border near Westhope, North Dakota. In the state of South Dakota, it runs from Olsonville to Herreid by way of Mission, Murdo, and Gettysburg. The route also runs through the capital Pierre as well as its suburb Fort Pierre. For much of its length, US 83 runs through rural areas, passing through the badlands and small portions of the Black Hills of the state.

South Dakota Highway 44 (SD 44) is a state highway in southern South Dakota that runs from U.S. Route 385 (US 385) west of Rapid City to Interstate 29 (I-29) south of Sioux Falls. It is just more than 379 miles (610 km) long.