U.S. Highway 90 Alternate is an alternate route to U.S. Highway 90 in Texas, United States, running from west of Seguin east via Seguin, Gonzales, Hallettsville, Eagle Lake, Rosenberg and Sugar Land to northeastern Houston. South of Downtown Houston, US 90 Alternate is built to freeway and near-freeway standards along a section of South Main Street.

U.S. Route 90 is a major east–west highway in the U.S. state of Texas with large portions of it running concurrently with I-10. US 90 begins at Bus. I-10 in Van Horn, travels through San Antonio and Houston, and continues on into the state of Louisiana.