U.S. Route 90 (US 90) in the state of Florida is the northernmost east–west United States Numbered Highway in the state. US 90 passes through the county seats of all 15 counties on its course in Florida, and it is also the road upon which many of the county courthouses are located. It is never more than six miles (9.7 km) from Interstate 10 (I-10) throughout the state. It runs as a two-lane highway through most of the sparsely populated inland areas of the Florida Panhandle, widening to four lanes through and near several towns. The speed limit is 55 mph (89 km/h) for all rural points west of Monticello, and it is 60 mph (97 km/h) on all rural points from where it enters Madison County as far as Glen St. Mary.

Interstate 10 (I-10) runs for 362 miles (583 km) in Florida as the easternmost section of an east–west Interstate Highway in the southern United States. It is also the eastern end of one of three coast-to-coast Interstates, along with I-80 and I-90. The highway runs east from the Alabama border, traveling through the Panhandle of Florida, serving the major cities of Pensacola, Tallahassee, Lake City, ending at Jacksonville, and carries the hidden Florida Department of Transportation (FDOT) designation of State Road 8 (SR 8).