U.S. Route 97 (US 97) is a major north–south route of the United States Numbered Highway System in the Pacific Northwest region. It runs for approximately 670 miles (1,078 km) through the states of California, Oregon, and Washington, primarily serving interior areas on the east side of the Cascade Mountains. The highway terminates to the south at a junction with Interstate 5 (I-5) in Weed, California, and to the north at the Canadian border near Osoyoos, British Columbia, where it becomes British Columbia Highway 97. Major cities on the US 97 corridor include Klamath Falls, Bend, and Redmond in Oregon; and Yakima, Ellensburg, and Wenatchee in Washington. A portion of the highway in California and Oregon is part of the Volcanic Legacy Scenic Byway.

Interstate 5 (I-5) is the main north–south Interstate Highway on the West Coast of the United States, running largely parallel to the Pacific Coast of the contiguous U.S. from Mexico to Canada. It travels through the states of California, Oregon, and Washington, serving several large cities on the West Coast, including San Diego, Los Angeles, Sacramento, Portland, and Seattle. It is the only continuous Interstate highway to touch both the Mexican and Canadian borders. Upon crossing the Mexican border at its southern terminus, the highway continues to Tijuana, Baja California, as Mexican Federal Highway 1 (Fed. 1). Upon crossing the Canadian border at its northern terminus, it continues to Vancouver as British Columbia Highway 99 (BC 99).