UAAP Season 78 was the 2015–2016 athletic year of the University Athletic Association of the Philippines (UAAP). It opened on September 5, 2015, almost two months after the usual July opening of the league during previous seasons, due to the shift in the academic calendars of four member universities, i.e. Ateneo, La Salle, UP and UST. It was hosted by the University of the Philippines.

The UST Growling Tigers and Tigresses are the college athletic teams representing the University of Santo Tomas in the University Athletic Association of the Philippines. They hold the most UAAP Overall Championships with 45 Seniors' Overall Championships and 21 Juniors' Overall Championships.