The UCLA–USC rivalry is the American collegiate athletics rivalry between the UCLA Bruins sports teams of the University of California, Los Angeles (UCLA) and USC Trojans teams of the University of Southern California (USC).

The USC Trojans are the intercollegiate athletic teams that represent the University of Southern California (USC) in Los Angeles. While the men's teams are nicknamed the Trojans, the women's athletic teams are referred to as either the Trojans or Women of Troy. The program participates in the Pac-12 Conference and has won 136 team national championships, 112 of which are National Collegiate Athletic Association (NCAA) national championships. USC's official colors are cardinal and gold. The Trojans have a cross-town rivalry in several sports with UCLA. However, USC's football rivalry with Notre Dame predates the UCLA rivalry by three years. The Notre Dame rivalry stems mainly from the annual football game played between these two universities and is considered the greatest intersectional rivalry in college football. The Trojans also enjoy a rivalry with the Stanford Cardinal. The USC Trojans are considered one of the most successful college athletic programs of all time.