UFC Fight Night: Blaydes vs. Lewis was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on February 20, 2021 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.

Derrick Lewis is an American professional mixed martial artist. He currently competes in the Heavyweight division in the Ultimate Fighting Championship (UFC), where he currently holds the record for most knockouts in UFC history. A professional competitor since 2010, Lewis has also competed for Bellator MMA and Legacy FC, where he was the Heavyweight Champion. As of March 12, 2024, he is #12 in the UFC heavyweight rankings.