UFC on ESPN: Blaydes vs. Daukaus was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 26, 2022 at the Nationwide Arena in Columbus, Ohio, United States.

Nationwide Arena is a multi-purpose arena in the Arena District of Columbus, Ohio. Since completion in 2000, the arena has served as the home of the Columbus Blue Jackets of the National Hockey League (NHL). It is one of two facilities in Columbus, along with Greater Columbus Convention Center, that hosts events during the annual Arnold Classic, a sports and fitness event hosted by actor, bodybuilder, and former Governor of California Arnold Schwarzenegger.