UFC on Fox: dos Anjos vs. Cowboy 2 was a mixed martial arts event held on December 19, 2015, at the Amway Center in Orlando, Florida.

Francis Zavier Ngannou is a Cameroonian and French professional mixed martial artist and professional boxer who is currently signed to the Professional Fighters League (PFL). He also competed in the Heavyweight division in the Ultimate Fighting Championship (UFC), where he was the reigning UFC Heavyweight Champion at the time of his departure from the promotion. Known for his punching power, Ngannou was widely viewed as the most destructive pure puncher in the UFC's heavyweight division; He ended seven of his fourteen UFC fights by knockout before the two-minute mark in the first round.